Denosyl®SD4 is recommended to improve hepatic glutathione levels to help maintain and protect liver function. 45% of dogs and cats with liver problems have a low hepatic glutathione level. Denosyl SD4 has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects hepatic cells. For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. When giving more than one tablet, the total daily dose may be provided as a morning and evening dose. For example, a daily dose of three tablets could be divided into two tablets in the morning and one tablet in the evening. FELINE AND CANINE DENOSYL SD4 ADMINISTRATION GUIDE Body weight Total daily administration and tablet size Up to 12 pounds (5.5 kg) One tablet of 90 mg 12 to 25 pounds (5.5-11 kg) Two tablets of 90 mg 25 to 35 pounds (11 -16 kg) One tablet of 225 mg 35 to 65 pounds (16 - 29.5 kg) Two tablets of 225 mg Over 65 pounds (29.5 kg +) Three tablets of 225 mg The number of tablets can be gradually reduced or may be increased at any time depending on the pet's needs.